During the malignant progression of tumors, a variety of signaling pathways are activated to participate in the proliferation, migration, angiogenesis and metabolic remodeling of tumor cells, among which IGFs play important regulatory roles (76)
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If GLP-1 drugs are producing a similar effect on the neural circuits involved in translating impulse into action, that would be consistent with the known distribution of GLP-1 receptors in brain regions including the prefrontal cortex, hypothalamus, and the mesolimbic dopamine system governing reward and craving
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