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In clinical trials, higher-dose retatrutide produced average weight loss of around 2428% over longer treatment periods

How GLP-1 works: GLP-1 is a hormone produced in the gut during digestion that may help to maintain a feeling of fullness and support metabolic health

If the medication is stopped, appetite can return, and some patients regain a significant amount of weight

Zepbound vs Wegovy: what patients usually want to know When patients ask their providers to compare Zepbound and Wegovy, the conversation usually comes down to three main factors: Mechanism of Action: Wegovy (semaglutide) works through the GLP-1 receptor alone

At validated doses, these mechanisms produce predictable metabolic outcomes