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An alternative interpretation for the first phase could be a rapid noncovalent interaction between PfGrx and GSSG in the vicinity of roGFP2, however, this seems less likely considering the smaller values for the structurally similar PfGrx mutants or, in particular, the rxYFP fusion constructs with ScGrx1 (Table 1)

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2.4 Mechanistic positioning versus standard-of-care Systematically, these polyphenols act in a multi-target and upstream manner, largely converging on NF-B/IL-23IL-17/JAK-STAT signaling axes [39]

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