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Leukocyte and neutrophil mean cell counts remained within normal range between screening, baseline and throughout the pivotal Phase 3 (leukocytes: normal range 4.010.0 109/L mean count at Day 182: 6.6 109/L with garadacimab [n = 39], 6.2 109/L with placebo [n = 24], neutrophils: normal range 2.07.0 109/L, mean count at Day 182: 4.0 109/L with garadacimab, 3.9 109/L with placebo) and OLE studies (At Month 12 [n = 140]: leukocytes: 6.4 109/L

Keep track of any changes in energy levels, skin appearance, or overall well-being

Young people have more of it about 200 ng/ml at age 20, but levels drop to 80 ng/ml by age 60

Since in all of the above studies the terminologies NAFLD/NASH were applied, these definitions will be used in this review

COX-2: Cyclooxygenase-2