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People who used a placebo lost 3% of their body weight

The article says patients with a history of cardiovascular disease, uncontrolled hypertension, arrhythmias, or coronary artery disease should not combine the two without extensive cardiologic evaluation

Compared with individuals with the E3/3 genotype, E2 carriers have a 20 % lower risk of coronary heart disease, and E4 carriers have a slightly higher risk [97]