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Exposure to pristane for 12 or 24 weeks promoted macrophage activation syndrome, characterized by hemophagocytosis in spleen and peripheral blood, as well as hypercytokinemia of IFN-, TNF-, IL-4, and IL-6

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Patients already avoiding steroids due to hepatic or renal concerns should be evaluated carefully, as the combined metabolic load of an aggressive peptide protocol warrants individual assessment

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