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Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling

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doi: 10.1038/nm.3128 206 SmitsMMTen KulveJSvan BloemendaalLTonneijckLMuskietMHAKramerMHHet al

In subjects with T2DM, weekly administration of tirzepatide at doses of 5 mg, 10 mg, or 15 mg was associated with greater weight loss compared to placebo ( 6.3 kg, 8.4 kg, and 9.4 kg, respectively), and 1.7 kg, 4.8 kg, and 7.2 kg greater weight loss compared to selective GLP-1 receptor agonists, demonstrating a dose-dependent effect sustained for up to 2 years [48]

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