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Through the CREB/BDNF axis, Sem increases remyelination and overcomes demyelination, therefore can amend experimental autoimmune encephalomyelitis (EAE)-induced multiple sclerosis in mice (Sadek et al

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Excess water intake rarely causes problems in healthy kidneys, though drinking excessive amounts (over 45 liters daily without extreme activity) can dilute blood electrolytes

The medication does not require carbohydrate elimination, nor would such an approach be clinically advisable for most patients