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The role played by ferroptosis in osteoarthritis: evidence based on iron dyshomeostasis and lipid peroxidation

Reactive oxygen species react with PUFAs in phospholipid membranes,initiating lipid peroxidation chain reactions that ultimately compromise membrane integrity and trigger ferroptotic cell death

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19 has also reported dendrite disruption in hippocampal CA1 region and behavioral disorders in neuron-specific GCL knockdown mouse

Dismantling and rebuilding the trisulfide cofactor demonstrates its essential role in human sulfide quinone oxidoreductase