Theoretical (mechanistic): the HGF/c-Met pathway governs growth, proliferation, and angiogenesis and is dysregulated in some cancers, so chronic potentiation raises a theoretical oncological concern

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doi:10.1016/j.fct.2014.01.016 [40] Swelum AA, El-Saadony MT, Abdo M, et al
Trends Endocrinol metabolism: TEM (2018) 29(6):38999
The GIP receptor activation in tirzepatide may enhance weight loss efficacy, but it also introduces distinct tolerability considerations