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As of September 2023 it is on the FDA's Category 2 list of bulk drug substances that may not be compounded due to significant safety risks, and the agency has scheduled a Pharmacy Compounding Advisory Committee (PCAC) review for July 2026 covering proposed uses in opioid withdrawal, chronic insomnia, and narcolepsy

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Maintenance uses 1-2mg weekly thereafter

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This guide provides exact CagriSema dosing protocols from clinical trials, practical titration schedules for simultaneous vs sequential starts, managing combined side effects during escalation, maintenance dosing after achieving weight loss, cost optimization strategies, and troubleshooting common dosing issues with the dual-peptide combination