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Notably, compensatory crosstalk may limit monotherapy efficacymelanoma cells escaping ferroptosis via FSP1 upregulation may become more dependent on necroptosis suppression, and vice versaunderscoring the rationale for co-targeting multiple pathways to avoid adaptive resistance (114)

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My dietitian, Kristen, and I, Ive been meeting for over two months or so, and I truly appreciate the guidance and concern concerns that she shares with me throughout the visit