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The medication works by mimicking the action of GLP-1, a naturally occurring hormone in the body that regulates appetite and food intake

renal impairment is not a labeled contraindication and calls for provider assessment and closer monitoring rather than avoidance

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Two main strategies informed by the NMDA-R hypofunction model have been systematically pursued: potentiation of the glycine NMDA-R site in add-on RCT targeting persistent negative and cognitive deficits (e.g., glycine, D-serine, sarcosine)

GLP-1 agonists are not a cure for rheumatic diseases, but they may offer a new approach to managing symptoms and improving outcomes, she said