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American Academy of Neurology guidelines on treating painful DPN recommend that clinicians evaluate oral, topical and nonpharmacologic therapies for patients with painful diabetic polyneuropathy, and emphasizes switching between drug classes rather than trying multiple agents within the same class if one fails [63]

Our findings demonstrated a significant correlation between low serum IGFBP3 levels and a strong association with CRC development [27], consistent with a study that identified a link with cancer susceptibility

doi: 10.1016/j.ajhg.2016.04.006 61

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Cancer Res 77(23):67466758 Akins NS, Nielson TC, Le HV (2018) Inhibition of glycolysis and glutaminolysis: an emerging drug discovery approach to combat cancer