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GH-induced increases in IGF-1 are associated with increased muscle protein synthesis and satellite cell activation (Baar, Journal of Applied Physiology )
For those interested in how semaglutide intersects with fitness-related body composition goals, the guide on losing weight on semaglutide without exercise and the broader discussion of how fast weight loss progresses are useful for setting expectations
That means you cannot legitimately place 10.8% for cagrilintide next to 24.2% for retatrutide and declare a winner, because those numbers come from different trials, different populations, different durations (26 vs 48 weeks), different doses, and critically a monotherapy figure for one versus a monotherapy figure for the other, while cagrilintides strongest data are actually as a combination
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