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Gastrointestinal adverse effects were most common, including nausea, vomiting, constipation, gastritis, and diarrhea, with higher incidence in Group 1

Unlike older growth hormone-releasing peptides (such as GHRP-6), Ipamorelin is highly selective and does not activate the brains appetite-stimulating receptors, making it ideal for patients trying to lose weight

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In conclusion, these data indicates GLP-1 but not metformin protects MG-induced beta cell apoptosis through improving mitochondrial function, and alleviating the prolonged AMPK activation

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