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Due to limited regulation, many are not produced in pharmaceutical-grade facilities or subject to rigorous quality assurance processes

Of note, there are at least five other mechanisms besides secondary neuroinflammation by which COVID can affect the CNS (direct viral invasion of neural tissue, autoimmunity, reactivation of herpesviruses, neurovascular dysfunction, the sequelae of hypoxic, and other metabolic disturbances), which may occur exclusively or in combination in some individuals with varying frequency and timing (for review, see [88])

Pediatr Neonatol 2019;60:579-80

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Some patients opt for weekly or bi-weekly sessions, while others choose to have monthly treatments