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The American Diabetes Association (ADA) Standards of Care and American College of Physicians (ACP) guidelines support the use of GLP-1 receptor agonists, including dual agonists like tirzepatide, as effective options for glycemic control and weight management

The gut-brain axis means that significant microbiome changes can affect mood and anxiety levels

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It reduced the drug-seeking behavior caused by stress, environmental cues, or exposure to the drug itself

Given the increasing interest in the potential use of incretins in cardiovascular diseases, conducting randomized controlled trials in this direction is warranted