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Notably, the hydroxyl group at the C4 position of the tetrahydropyran ring of substrate 7 also stabilizes the GSH-thiolate through an additional hydrogen bond (Extended Data Fig

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Gallbladder issues, for instance, tend to develop over weeks of treatment

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For our calculations, we used APC 5071, which had a CY 2025 payment rate of $703.59 at the time the application was received

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Systemic lupus erythematosus (SLE) involves immune dysregulation, and GLP-1 receptor agonists interact with immune pathways, demanding individualized safety assessment before treatment begins

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4.2 Real-world evidence: signal strength and heterogeneity of evidence Real-world evidence is derived primarily from spontaneous reporting systems and cohort studies

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