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For detailed information on each compound, see

10.1002/adfm.202111208 58 LiS.KimM

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Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochem Pharmacol. 2018 Jul;154:161-171. doi: 10.1016/j.bcp.2018.05.003. Epub 2018 May 5. PMID: 29738706; PMCID: PMC6015571

Overall, current evidence suggests that selenium supplementation may hold greater potential in individuals with low selenium status, whereas its generalized use remains to be validated in larger and more rigorously designed trials