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Mice with TrxR1/Gsr-null livers exhibit full recovery from sterile acute oxidative stress induced by surgical hepatic ischemia/reperfusion injury [108], indicating that antioxidant defenses in TrxR1/Gsr-null cells are at least not so deficient as to be at a critical lethal-threshold

Zheng, X

These findings do not establish general repair of damaged human DNA or prevention of mutations

More human clinical studies are needed to prove the effectiveness and specific effect of butyrate on obesity, and more diversified experimental models are needed to determine the effective conditions of butyrate in obesity

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