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Overall, our results suggest that the AP is responsible for the appetite-suppressing effects of GIPR agonism but that GIP receptors in the hypothalamus underlie the ability of GIPR antagonism to enhance the weight loss effects of GLP-1R and amylin receptor agonists

But now the quest for randomized evidence of CVD benefits from treating obesity may soon yield dividends, thanks to two major multicenter trials of anti-obesity medications one run by the Cleveland Clinic Coordinating Center for Clinical Research (C5Research) and one with a Cleveland Clinic cardiologist as co-principal investigator