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Because Ex-4 induced AKT phosphorylation in the co-culture and its beneficial effects on DRG neurons and IFRS1 cells were attenuated by phosphatidyl inositol-3-phosphate-kinase (PI3K) inhibitor LY294002, the myelination-inducible activities of Ex-4 may be attributable to the activation of PI3K/AKT signaling pathway in both cells (Figure 1A)

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