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This dual mechanism provides additional metabolic benefits, enhancing insulin secretion, reducing glucagon, and further boosting weight loss compared to single-action GLP-1 agonists like semaglutide

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If you previously ate 2,200 calories per day and now you are eating 1,200 to 1,400, you have cut your nutrient intake by roughly 40 percent

Furthermore, its short half-life of less than 3 h (Min et al., 2025) necessitates twice-daily injections to maintain efficacy, which can be a limiting factor for long-term patient adherence