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However, hepatocytes do not express GLP-1R, making it difficult to appreciate its liver health advantages

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This enabled evaluation of GLP-1's impact relative to standard care, which may include other anti-diabetic or weight loss interventions

Later, it was approved for use in individuals with a body mass index (BMI) of 27 or above weight gain and those with at least one weight-related health problem, such as high blood pressure or type 2 diabetes, to promote weight loss