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Can GLP-1 (Glucagon-like peptide-1) receptor agonists be used in combination with Actos (Pioglitazone) for patients with type 2 diabetes?

Mingorance C, del Pozo MG, Herrera MD, de Sotomayor MA

Unlike sarcopenia, which requires both loss of muscle quantity and reduced function, lean mass reduction is a body-composition outcome most often assessed using dual-energy X-ray absorptiometry (DXA) or bioimpedance analysis (BIA) [2, 20]

The specific threshold and mechanisms that govern the transition from therapeutic to detrimental effects remain unclear

Functional brain imaging techniques, such as functional magnetic resonance imaging (fMRI) and fluoro-deoxy-glucose positron emission tomography (FDG-PET), have shown that the orbitofrontal cortex (OFC) is activated when individuals consume food until they feel full