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Substrate Specificity Glutathione peroxidases (GPXs) have a diverse range of oxidizing substrates

In psoriatic lesions, the NF-B activity can be upregulated by ROS ( FIGURE 3 3.2 ROS-induced damage to cellular biological macromolecules ROS possess strong oxidizing properties and can directly or indirectly attack intracellular biological macromolecules, disrupting cellular structure and function, thereby mediating cell apoptosis or abnormal proliferation and participating in the pathological process of skin diseases (Figure 4)

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