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86 In patients with T2D and high cardiovascular risk, semaglutide use has resulted in fewer serious cardiac and kidney disorders compared to placebo but is linked to worsening diabetic retinopathy, likely due to rapid glucose reduction

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This understanding can help you identify triggers and help you develop strategies to stop food cravings

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GLP-1RAs can modulate intracellular calcium homeostasis to prevent reperfusion injury directly in cardiomyocytes [164]

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However, the lower dose of semaglutide used and a focus on patient-reported outcomes rather than on cardiovascular events are limitations of STEP-HFpEF DM

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