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doi: 10.1001/jama.2009.1622 248

A recurring theme across non-incretin metabolic peptides is that early development efforts were constrained by pleiotropy, cardiovascular effects, or incomplete receptor characterization rather than by lack of metabolic relevance

GLP-1 receptor agonists suppress appetite and slow gastric emptying, which commonly leads to rapid, substantial weight loss: often 1520% of total body weight within a year

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