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The Lean Mass Question Separating Signal From Panic Muscle loss has become the most discussed long-term concern around GLP-1 therapy

Both treatments offer distinct benefits, making them suitable for different preferences and health goals

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Preoperative planning requires particular attention: according to 2024 multi-society guidance (including the American Society of Anesthesiologists), most patients can continue GLP-1 receptor agonists perioperatively

In one standout phase 2 trial, retatrutide demonstrated up to 29% body weight loss over 68 weeks, resetting the standard for weight loss medications