95,96 Pharmacological agents such as GLP-1 RAs mimic endogenous GLP-1 regulatory activities, aiding in T2D management by increasing the incretin effect, postprandial insulin release, increased satiety, and decreased glucagon secretion, thus improving glycemic control
The combination leaves many patients running low on sodium, potassium, and magnesium without realizing it
Furthermore, GLP-1RAs can increase diuretic and natriuretic actions through changes in renal hemodynamics and inhibition of the sodium-hydrogen exchanger 3 in the renal proximal tubule [56]
But the data didnt show Wegovy lowered the risk of cardiovascular death by a statistically significant margin
Table of Contents: What is the difference between Semaglutide GLP-1, Ozempic, Wegovy, and Mounjaro