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For example, a critical nucleotide position in RNaseH-recruiting ASOs has been identified recently as a hot spot for adverse ASOprotein interaction, leading to a clear improvement of therapeutic index 14

Digestive issues also can lead to cognitive issues (brain fog), mood issues (anxiety, depression), inflammation (joint pain), and a host of other symptoms

23,24 However, effect sizes vary with dose, extract standardization, and study duration, underscoring the need for larger, longer, and more standardized trials

The catch is that this synergy is mostly mechanistic speculation