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Dosages used in rodent studies range from 10mg/kg/day to 150mg/kg/day [1, 6, 11]

Outcome measures Primary outcome measures included change in creatinine-standardized, urinary F2-isoprostanes (F2-isoP) and urinary 8-hydroxy-2-deoxyguanosine (8-OHdG)

The higher-exposure group showed less body-weight and fat-mass gain than controls

In clinical trials, the half-life of cagrilintide (0.164.5 mg) ranged from 159 to 195 hours, and the elimination half-life ranged from 7 to 8 days, making cagrilintide suitable for once-weekly dosing

While ultrasound is commonly used as an initial noninvasive method to detect hepatic fat, biopsy remains the gold standard for diagnosis