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Overall, nine studies (six clinical studies, two case series, and one survey) were included

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The progression over 24 months of follow-up of ALSFRS-R total score and FVC% were evaluated using repeated measures linear mixed models with random intercept and slope, with, separately, ALSFRS and FVC% as dependent variable and treatment (not treated or treated with ALCAR), time (month 024) and treatment time interaction as independent variables

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