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4.4 The role of mutations in the emergence and prognosis of NDDs Studies implicate germline, de novo , and somatic mutations in pathologies, including NDDs (Acuna-Hidalgo et al., 2016
Some of these lifestyle behaviors are relatively straightforward to adopt, while others, such as managing chronic conditions or engaging in cognitivelystimulating activities, are multifaceted and may require support from a physician or a structured program
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While formal guidelines do not yet exist for PDA, the human-data signals allow us to construct practical, hypothesis-driven frameworks for peri-operative use
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