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Vitamin B12 is crucial for the synthesis of neurotransmitters such as serotonin and dopamine, which regulate mood and emotional balance

Structurally, it is the only GPX isoform with a monomeric conformation and a unique catalytic tetrad including Sec, Gln81, Trp136, and Asn137 that enables it to reduce complex hydroperoxides in situ even within membranes ( Transcriptionally, GPX4 expression is promoted by Nrf2 and ATF4 in response to oxidative or endoplasmic reticulum stress

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2-(RS)-n-propylthiazolidine-4(R)-carboxylic-acid (PTCA)

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