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Researchers modified the original peptide structure to create longer-acting formulations with various strategies: liraglutide (once daily) uses fatty acid albumin-binding, dulaglutide (once weekly) employs an Fc-fusion approach, exenatide extended-release (Bydureon, once weekly) utilises microsphere technology, and semaglutide (once weekly) incorporates fatty acid modifications

de la Cuesta-Zuluaga J, Mueller NT, Corrales-Agudelo V et al (2017) Metformin is associated with higher relative abundance of mucin-degrading Akkermansia muciniphila and several short-chain fatty acid-producing microbiota in the gut

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Injection site reactions are among the most frequently reported adverse effects of peptide therapeutics

We report the crystal structures of cFSP1 (residues 12373, hereafter named cFSP1 N ) in its substrate-free and ubiquinone (CoQ 1 )-bound forms at 2.0 and 2.6 resolution (Supplementary Table 1), respectively