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PMID: 26236730 Published Research Highlights Discovery 1973 Tripeptide Identified in Human Serum Pickart and Thaler first identified the GHK sequence in human plasma, discovering a tripeptide that prolonged survival of normal liver cells and stimulated growth in cell culture models

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This phenomenon is generalisable to mammalian modelsthe mRNA expression of BRCA1 and H2AX, key DNA damage repair genes, are synchronously reduced when the primordial follicles of the ovaries of young (~ 9-week-old) and old (32-week-old) rats are compared, further validating the systematic decline in DNA repair efficiency during reproductive ageing [37, 38]

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