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The most common side effects of metformin include: Asthenia (weakness) Diarrhea Nausea/Vomiting Flatulence (passing gas) Discoloration (yellowing) of the fingernails or toenails Constipation Headache Indigestion Heartburn Metallic taste Metformin may also cause a vitamin B12 deficiency over time because it potentially interferes with the absorption of this vitamin

[DOI] [PMC free article] [PubMed] [Google Scholar] 184.Azman M., Sabri A.H., Anjani Q.K., Mustaffa M.F., Hamid K.A