semaglutide for diabetes FDA Clears Cardiac Risk Reduction in Diabetic Patients Use of new diet drugs

Another study published a month earlier in JAMA Network Open found that people with Type 2 diabetes who used GLP-1s had a slightly increased risk of diabetic retinopathy

12,128 More importantly, the high mortality risk associated with types 1 and 2 diabetes occurs primarily in those with CKD

NEJM 2023 What this means: Even the lowest dose (1mg) produced clinically meaningful weight loss (-8.7%) The 12mg dose showed no plateau at 48 weeks

It is sterile but not potent

N Engl J Med 362:16751685 Cusi K, Orsak B, Bril F et al (2016) Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus: a randomized trial