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First, SELECT was not a primary prevention trial, and the data should not be extrapolated to all individuals with overweight and obesity to prevent major adverse CV events

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Several neurocognitive peptides have shown memory and cognition effects in animal models and small human studies, primarily through pathways involving BDNF (brain-derived neurotrophic factor), nerve growth factor, and synaptic plasticity

On the other hand, compounded semaglutide is generally not covered by insurance