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A more commonly used procedure for measuring GSH and GSSG now is high performance liquid chromatography (HPLC) (Fariss and Reed, 1987)

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Recent pilot studies and small clinical trials in people with diabetic neuropathy found improvements in blood flow to the skin and reductions in pain, though the number of patients studied has been small and treatment plans varied (Tassone et al., 2023)

The essential nature of GPX4 is demonstrated by the fact that genetic disruption of the entire Gpx4 gene in homozygous Gpx4 knockout causes in utero fetal death by midgestation (Imai et al., 2003)