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"Because I had done it, I thought it was going to be OK," she said

For instance, new research presented at ACC.25 in March 2025 indicated that tirzepatide improved kidney function and cardiovascular outcomes in patients with obesity and heart failure with preserved ejection ejection (HFpEF) compared with placebo at one year, showing a 38% lower rate of cardiovascular death or worsening heart failure

However, chronic scheduling inconsistency or frequent early doses could compress dosing intervals and increase weekly exposure, warranting provider oversight to maintain therapeutic stability

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Secondly, significant weight loss and the resultant change in the inflammatory phenotype of obese adipose tissue would reduce the release into the circulation of key pro-fibrotic pro-inflammatory cytokines/adipokines such as TNF-, IL-6, leptin [31], visfatin and resistin, and increase levels of anti-fibrotic adipokines such as adiponectin [32]