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To date, clinical data have been reported for two dual GIP/GLP-1 receptor agonists

A research review demonstrated that high-fiber foods, particularly those rich in fermentable or soluble fiber, significantly boost GLP-1 secretion compared to low-fiber foods

Retatrutide is undergoing further research to evaluate its long-term cardiovascular benefits, neuroprotective potential, and impact on metabolic diseases

Patients with T2DM experience a significant decline in the incretins functional properties which causes delayed and reduced insulin release after glucose administration and impairs glucose tolerance [12,13,14]

Licensed options in the UK include orlistat (oral), semaglutide 2.4 mg (Wegovy, approved by NICE TA875 for eligible patients), and tirzepatide (Mounjaro for type 2 diabetes