This article reviews the pathophysiology of acetaminophen metabolism, the clinical and diagnostic clues of an acute overdose, differential diagnoses, and management approaches including the use of the antidote, N -acetylcysteine (NAC), for acute acetaminophen overdose and toxicity in pediatric patients
Moreover, some clinical trials of the combination of DSF and copper have been completed (NCT00742911 and NCT03034135) or are in progress (NCT04265274, NCT03714555, NCT03363659, and NCT02715609), providing a potential strategy for tumor therapy
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System Xc - , a heterodimer composed of xCT (SLC7A11) and 4F2 (SLC3A2) (51), facilitates the import of cystine and the export of glutamate, hence supplying precursors for glutathione production
Targeted Delivery: Liposomes can be engineered to deliver glutathione to specific cells or tissues
