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Mechanistically, Clostridium probiotics may modulate ADs via multiple therapeutic mechanisms, including regulating gut microbiota composition, replenishing beneficial metabolites to restore intestinal barrier integrity, correcting dysregulated immune cell differentiation and homeostasis, and balancing pro- and anti-inflammatory cytokine levels

The original epithalamin extract received approval in Russia specifically for menopause-related symptoms, suggesting relevance for women during hormonal transitions

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