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The oral version, which comes as a daily tablet, was originally developed for managing type 2 diabetes and follows a different dosing path

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By Lana Pine | Published on February 26, 2026 5 min read A new head-to-head clinical trial published in The Lancet suggests that an investigational once-daily pill, orforglipron, may offer stronger blood sugar and weight loss benefits than oral semaglutide for adults with Type 2 diabetes who are not adequately controlled on metformin