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This principle of gradual adjustment also applies when discontinuing the medication
A post-hoc analysis of this trial revealed that tirzepatide users experienced an amelioration of the atherogenic lipoprotein profile with reduction in large triglyceride rich lipid particles, small low-density lipoprotein particles (LDLP) and apolipoprotein B, consistent with the significant improvement of insulin sensitivity
phase 2 trial data confirm gastrointestinal side effects are common, though heartburn was not consistently itemised as a standalone adverse event
Five studies (n=247) utilised gastric emptying scintigraphy
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