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2010), ligaments (Lovric-Bencic et al

Targeting of ECM molecules and their metabolizing enzymes and receptors for the treatment of CNS diseases

The 4.8 mg dose emerged as the optimal balance between efficacy and tolerability

Acknowledgements The studies reported in this paper from the authors' laboratory have been supported, in part, by grants from the National Institute of Health (P30CA08748-41), Jack and Susan Rudin Foundation, David H Koch Foundation, and the Prostate Cancer Research Award, Experimental Therapeutics Center at Memorial Sloan-Kettering Cancer Center and the DeWitt Wallace Research Fund