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Published April 27, 2023

The MINE creators "arbitrarily created" (their own words, quoted verbatim) minimum and maximum species-wide cutoffs for each of those four echo measurements by the severity of the MVD -- scores 1, 2, 3, and 4 -- based upon "the authors' clinical experience" (again, verbatim)

doi: 10.1016/j.physbeh.2005.08.066 112 SclafaniASpringerD

Nasally delivered tiny peptides offer a viable, cost-effective, and patient-approved alternative to continuous CGRP blocking without cardiovascular hazards [113]